β catenin in 2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9696	β-catenin-IN-2		Wnt/beta-catenin
	β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.		Wnt/beta-catenin
T41094	Wnt/β-catenin agonist 2		GSK-3 , Wnt/beta-catenin
	Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist. Wnt/β-catenin agonist 2 can be used in the study of diseases related to signal transduction and is closely related to cancer inva...		GSK-3 , Wnt/beta-catenin
T9557	TNIK-IN-2		Wnt/beta-catenin
	TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which is a downstream signal protein of the Wnt/β-catenin pathway.		Wnt/beta-catenin
TL0007	Bisdemethoxycurcumin	Curcumin III,Didemethoxycurcumin	Epigenetic Reader Domain , Wnt/beta-catenin
	Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by mac...		Epigenetic Reader Domain , Wnt/beta-catenin
T2310L	CHIR-99021 HCl	CT99021 HCl,Laduviglusib HCl	GSK-3
	CHIR-99021 HCl (Laduviglusib HCl) is a highly potent and selective inhibitor of GSK-3α/β, with IC50 values of 10 nM and 6.7 nM respectively. It demonstrates remarkable selectivity for GSK-3, with over 500-fold selectivit...		GSK-3
T4S1943	Kirenol	Kirel	Wnt/beta-catenin
	1. Kirenol (Kirel) has anti-oxidant, anti-inflammatory, anti-allergic, and anti-arthritic activities. 2. Kirenol is effective against gram-positive bacteria. 3. Kirenol possesses antitumor action on human chronic myeloid...		Wnt/beta-catenin
T5S0754	Isoquercetin	3-Glucosylquercetin,Hirsutrin,Isoquercitrin,Quercetin 3-o-glucopyranoside	NF-κB , Wnt/beta-catenin , NO Synthase
	1. Isoquercetin (3-Glucosylquercetin) is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercetin may be as a potential therapeutic agent against neurodegeneration in ...		NF-κB , Wnt/beta-catenin , NO Synthase
T78120	β-catenin-IN-6
	β-Catenin-IN-6 is an inhibitor of the canonical Wnt/β-catenin signaling pathway, effectively impeding the proliferation of human colorectal cancer cells and demonstrating efficacy in a β-catenin/RK3E mouse model [1] [2].
T35547	YW1128
	YW1128 is an inhibitor of Wnt/β-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.1 It decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein ...
T75941	Foxy-5 TFA
	Foxy-5 TFA, a WNT5A agonist and mimicking peptide of WNT5A (a non-canonical Wnt family member), induces cytosolic free calcium signaling without altering β-catenin activation. This compound inhibits the migration and inv...
T79546	BMP agonist 1
	BMP Agonist 1 (compound 2 b) is a small-molecule stimulator of bone morphogenic protein (BMP) signaling, crucial for the differentiation of C2C12 cells. It acts by inhibiting GSK3β and enhancing β-catenin signaling, ther...
T75956	Fz7-21 TFA
	Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA, a potent peptide antagonist, selectively targets and binds to the FZD7 CRD subclass, significantly altering its CRD conformation and the structure of its lipid-binding groove. This com...
T65994	(6S)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
	Wnt signaling is required for direct multiple biological processes and also plays key roles in the pathogenesis of various diseases. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is a ...
TN2775	2-Methoxystypandrone		MMP , BCL , IκB/IKK , GSK-3 , TNF , NOS , NF-κB , Wnt/beta-catenin , COX , JAK , STAT
	2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-ÎºB signaling to limit the inflammation and oxidative stress for preservation of BBB integrit...